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Weston MD, Kelley PM, Overbeck LD, Wagenaar M, Orten DJ, Hasson T, Chen ZY, Corey D, Mooseker M, Sumegi J, et al.Defective myosin VIIA gene responsible for Usher syndrome type 1B. Weil D, Blanchard S, Kaplan J, Guilford P, Gibson F, Walsh J, Mburu P, Varela A, Levilliers J, Weston MD, et al.Gene mapping of Usher syndrome type IIa: localization of the gene to a 2.1-cM segment on chromosome 1q41. Kimberling WJ, Weston MD, Möller C, van Aarem A, Cremers CW, Sumegi J, Ing PS, Connolly C, Martini A, Milani M, et al.Assignment of an Usher syndrome type III (USH3) gene to chromosome 3q. Sankila EM, Pakarinen L, Käriäinen H, Aittomäki K, Karjalainen S, Sistonen P, de la Chapelle A.Mapping recessive ophthalmic diseases: linkage of the locus for Usher syndrome type II to a DNA marker on chromosome 1q. Lewis RA, Otterud B, Stauffer D, Lalouel JM, Leppert M.Localization of Usher syndrome type II to chromosome 1q. Kimberling WJ, Weston MD, Möller C, Davenport SL, Shugart YY, Priluck IA, Martini A, Milani M, Smith RJ.A newly identified locus for Usher syndrome type I, USH1E, maps to chromosome 21q21. Chaïb H, Kaplan J, Gerber S, Vincent C, Ayadi H, Slim R, Munnich A, Weissenbach J, Petit C.Localization of the Usher syndrome type ID gene (Ush1D) to chromosome 10. Wayne S, Der Kaloustian VM, Schloss M, Polomeno R, Scott DA, Hejtmancik JF, Sheffield VC, Smith RJ.Localization of two genes for Usher syndrome type I to chromosome 11. Smith RJ, Lee EC, Kimberling WJ, Daiger SP, Pelias MZ, Keats BJ, Jay M, Bird A, Reardon W, Guest M, et al.Tightly linked flanking microsatellite markers for the Usher syndrome type I locus on the short arm of chromosome 11. Keats BJ, Nouri N, Pelias MZ, Deininger PL, Litt M.Genetic mapping of the gene for Usher syndrome: linkage analysis in a large Samaritan kindred. Bonné-Tamir B, Korostishevsky M, Kalinsky H, Seroussi E, Beker R, Weiss S, Godel V.Linkage of Usher syndrome type I gene (USH1B) to the long arm of chromosome 11. Kimberling WJ, Möller CG, Davenport S, Priluck IA, Beighton PH, Greenberg J, Reardon W, Weston MD, Kenyon JB, Grunkemeyer JA, et al.Genetic heterogeneity of Usher syndrome type 1 in French families. Larget-Piet D, Gerber S, Bonneau D, Rozet JM, Marc S, Ghazi I, Dufier JL, David A, Bitoun P, Weissenbach J, et al.A gene for Usher syndrome type I (USH1A) maps to chromosome 14q. Kaplan J, Gerber S, Bonneau D, Rozet JM, Delrieu O, Briard ML, Dollfus H, Ghazi I, Dufier JL, Frézal J, et al.Clinical findings in obligate carriers of type I Usher syndrome. Wagenaar M, ter Rahe B, van Aarem A, Huygen P, Admiraal R, Bleeker-Wagemakers E, Pinckers A, Kimberling W, Cremers C.Usher's syndrome type III: ENG findings in four affected and six unaffected siblings. Karjalainen S, Teräsvirta M, Kärjä J, Käriäinen H.Progressive hearing loss in Usher's syndrome. Karjalainen S, Pakarinen L, Teräsvirta M, Käriäinen H, Vartiainen E.Gorlin RJ, Tilsner TJ, Feinstein S, Duvall AJ., 3rd Usher's syndrome type III. Usher syndrome: clinical findings and gene localization studies. Kimberling WJ, Möller CG, Davenport SL, Lund G, Grissom TJ, Priluck I, White V, Weston MD, Biscone-Halterman K, Brookhouser PE.Retinitis pigmentosa combined with congenital deafness with vestibulo-cerebellar ataxia and mental abnormality in a proportion of cases: A clinical and genetico-statistical study. Links to PubMed are also available for Selected References. Get a printable copy (PDF file) of the complete article (1.2M), or click on a page image below to browse page by page. Full textįull text is available as a scanned copy of the original print version. As regards the remaining six USH1 families, the linkage analysis did not provide conclusive data, although two of them show slight linkage to markers located on chromosome 3q (Zmax=1.880, theta=0.000 for D3S1279), the same location that had previously been assigned to some USH3 families. It is important to note that one of our families linked to the USH1B locus shows interesting intrafamilial clinical variability. Our findings suggest considerable genetic heterogeneity in the Spanish USH1 population. Of 18 USH1 families studied by linkage analysis, 12 (67%) showed significant lod score values for locus D11S527 (Zmax=14.032, theta=0.000) situated on chromosome 11q. With regard to Usher type I (USH1), several subtypes have been described, the most frequent being USH1B located on chromosome 11q13.5. The disorder is clinically and genetically heterogeneous. Usher syndrome (USH) is an autosomal recessive hereditary disorder characterised by congenital sensorineural hearing loss and gradual visual impairment secondary to retinitis pigmentosa (RP). While an inkjet printer costs less upfront, it is typically more expensive to operate. A laser printer will cost you more upfront but will be less expensive to operate. The most cost-effective option will depend on how frequently you plan to use your printer. Find out how many pages you can expect to get out of each cartridge, as well as how much replacements cost. Consider how much toner or ink you’re going to use to see which one is the most cost-effective. Inkjet printers use liquid ink while laser printers use a powdered toner. You can even have the ability to use different types and sizes of paper. These types of copiers can usually be networked and include a variety of printing, scanning, and faxing capabilities. Officer copiers are larger and often freestanding. You can find some low-priced copiers, but they will likely not meet the needs of most small businesses. MFPs that are made for home offices are usually desktop size to save space. What are the Differences Between Copiers and MFPs?Īs you consider whether you need a copier or an MFP, it’s important to know the differences that exist. You’ll want to have an idea of the types and paper sizes you’ll be using the most to get the right MFP. Look at the paper capacity or tray or cassette of a printer as well as the sizes of paper it can print on. Production printers have a much higher resolution than office printers, and typically are bundled with high-end graphics software that allows the end user to achieve a wide range of specific Pantones. Production printing and office printing have different graphics specs. Graphics are important when you’re talking about MFPs. This is vital if your business does a lot of scanning of large documents. This means you don’t have to manually replace each page. Automatic document feederĪn automatic document feeder or ADF, as mentioned above, takes several pages and feeds the paper one page at a time into a scanner. The duplex feature enables double-sided scanning. Document feeders are essential if you want to be able to scan a large volume of documents. If you want to have the ability to have scanned documents, you want to make sure that your printer has an automatic document feeder or duplex scanning abilities. At least 35 to 50 ppm is often recommended for a small business or midsize business with average printing needs. You want to look for a printer that’s fast enough to keep up with your workflow. Print speeds are often listed on spec sheets as “ppm” or pages per minute. When you’re looking at an all-in-one machine, print speed is one of the most crucial functions to examine. The more memory you have, the faster the machine can work. If you have a high volume of images or printing jobs, you’ll want a machine that has a higher memory capacity. The storage space can also range from 1GB to 1TB. An internal drive is similar to any other computer hard drive.ĭepending on the size of the copier, the RAM can range from 256 MB to 2 GB. Many MFPs have an internal memory that allows them to retain many documents and scans. Let’s explore some of the functions that may have you wanting a new device. Many MFPs share some key features that make them optimal for home offices and traditional offices alike. What are the Key Features of Office Copiers and Multifunction Printers? Many companies tend to go for an MFP versus a traditional copier because they can complete more functions with a single machine and have more technology. If you want to do more than that, then you’ll want to opt for a multifunctional printer. Is There a Multifunctional Copier?Ī copier generally has a single focus which is to make copies. MFPs are designed to help businesses be as efficient as possible while cutting supply costs. An MFP can also handle both monochrome and color printing technology. When it comes to office equipment, many prefer an MFP because of all of the tasks it can perform besides copying. If you opt for an even fancier model, you may be able to do things like sorting, stapling, and hole punching. An MFP can scan to locations like email, USB drives, and cloud-based services. They not only print, but they also copy, scan, fax, and do other tasks as well. Multifunctional printers have several functions. We’re going to dive deeper into them so that you can decide if that’s the best choice for you or if you just simply need a copier. If you want to do it all, you may be looking at a multifunctional printer.Ī multifunction printer has several key features that are worth looking into. Do you want to print, copy, fax, or do it all? Knowing the answer to this question will help you choose the right machine for the job. That’s why we’re here to help.įirst, you need to know what you want to be able to do with your printer. If you’ve been in the market for a new printer, you may be confused by all of the choices out there. No, any online countdown timer will not work if your computer is on standby or in sleep mode. Does a Countdown Timer Work in Sleep Mode? If you'd like to start a countdown timer with a date and time, you can use the online countdown instead. Because the timer clock shows a large on-screen countdown, it is great for being used in classrooms or when cooking, studying, practicing for an exam, or exercising. You can create a timer on any computer or mobile device with an internet or Wi-Fi connection. This shows the name, duration, and time stamps for your recent timers. Once your timer(s) have run, a table will appear below under Timer Data. Press Stop to stop your timer and set a new timer.Press Restart to stop your timer and replace it with a new one.Press Pause to temporarily stop your timer.While your timer clock is running, you can: Make sure your computer volume is on or turned up to hear the alarm. Once completed, your chosen sound will be played. Chess Clock - A free online Chess Clock Chess Timer - Clock goes UP, Timer goes Down. Clock Countdown - It goes round and round. Like a stopwatch, a progress bar will appear, showing the percentage of your countdown timer's completion. Split Lap Timer - Split Laps, record times. On screen, you can check how long it is left and what time it finishes via the digital clock. Once set, your timer with alarm will begin counting down. To create multiple timers, open a new tab and simply repeat these steps. Add a Timer name or leave it as the default. Use this calculator to add or subtract time (days, hours, minutes, seconds) from a starting time and date.Set your Alarm sound by clicking the arrow and selecting from the list.Set the number of Hours, Minutes, and Seconds you want the timer to run for, or choose a pre-selected minute or second timer from the options listed.Using the timer is easy, and you can start it in just a few simple steps: Once set, the online alarm will sound at your computer's volume. You can set a timer in hours, minutes, or seconds quickly and easily from any computer or mobile device. The online timer is an easy-to-use computer timer you can use to display a large countdown on the screen. 19 minute timer will count for 1,140 seconds. When the timer is up, the timer will start to blink. You can pause and resume the timer anytime you want by clicking the timer controls. To run stopwatch press 'Start Timer' button. Online countdown timer alarms you in nineteen minute. This is the easiest way to set a live timer online. Reset 19 minute timer to set alarm for 19 minute minute from now. You can configure the alarm clock appearance (text color, type. Try the Fullscreen button in classrooms and meetings :-) Start. When setting the alarm, you can click the 'Test' button to preview the alert and check the sound volume. A cool little 19 Hour Timer Simple to use, no settings, just click start for a countdown timer of 19 Hours. The alarm message will appear, and the preselected sound will be played at the set time. You can access this via the internet without downloading an app. Set the hour and minute for the online alarm clock. On any browser, you can use a free online timer to set a timer on your computer. The international healthcare community has previously considered the rate of 10% and 15% to be ideal for caesarean sections. In 2012, about 23 million C-sections were done globally. The method of delivery does not appear to have an effect on subsequent sexual function. Established guidelines recommend that caesarean sections not be used before 39 weeks of pregnancy without a medical reason. The increased risks include breathing problems in the baby and amniotic fluid embolism and postpartum bleeding in the mother. They also typically take longer to heal from, about six weeks, than vaginal birth. Ĭ-sections result in a small overall increase in poor outcomes in low-risk pregnancies. Often, several days are required in the hospital to recover sufficiently to return home. A woman can typically begin breastfeeding as soon as she is out of the operating room and awake. The uterus is then opened with a second incision and the baby delivered. An incision of about 15 cm (6 inches) is then typically made through the mother's lower abdomen. A urinary catheter is used to drain the bladder, and the skin of the abdomen is then cleaned with an antiseptic. It may be done with a spinal block, where the woman is awake, or under general anesthesia. Ī C-section typically takes 45 minutes to an hour. The World Health Organization recommends that caesarean section be performed only when medically necessary. A trial of vaginal birth after C-section may be possible. A caesarean delivery may be performed based upon the shape of the mother's pelvis or history of a previous C-section. Reasons for the operation include obstructed labor, twin pregnancy, high blood pressure in the mother, breech birth, shoulder presentation, and problems with the placenta or umbilical cord. Caesarean section, also known as C-section or caesarean delivery, is the surgical procedure by which one or more babies are delivered through an incision in the mother's abdomen, often performed because vaginal delivery would put the baby or mother at risk. The Stunner uses a multipulse rocket motor, while the MBDA powers the Meteor missile with a ramjet-augmented rocket. Several options are available to modern missile designers. It could more closely reflect the multimode guidance system installed in the Raytheon/Rafael Stunner surface-to-air missile, which combines radar and infrared sensors into a dolphin nose-shaped radome.Ī “new, high-performance propulsion section” will accelerate the Peregrine to supersonic speed to achieve potentially slightly better range than the AIM-120, but Noyes declined to describe the specific type of propulsion technology selected for the new missile. A multimode guidance system places the Peregrine in a different category than the radar-guided AIM-120 and infrared homing AIM-9X. The missile is guided to the target with a “multimode autonomous seeker,” says Noyes, but he declined to elaborate. Lockheed designed the Cuda as a hit-to-kill weapon, but the Peregrine destroys the target with a blast-fragmentation warhead. Although Peregrine shares a common stature with Lockheed's Cuda concept, there are distinct differences. (68 kg), or roughly half the length and mass of the 12-ft., 335-lb. (1.8 m) and a total weight of about 150 lb. Raytheon lists the Peregrine with a length of 6 ft. The Cuda received support from an Air Force Research Laboratory project called Small Advanced Capabilities Missile. The Peregrine also fits into a new category typified by the 2013 unveiling of Lockheed Martin's Cuda concept, which offered the Air Force a missile with AIM-120-like range-or slightly better-in a package half the size and weight. In addition to the MBDA Meteor, the PL-15 is being developed by China and the Vympel K-77M has been ordered by the Russian government. Raytheon's internal development project follows the introduction of multiple weapons boasting longer range than the nearly three-decade-old AIM-120 design. “What we see it as is a complement to our Amraam and AIM-9X,” Noyes says and international customers that want AIM-120 performance in a smaller package to double missile loads in the internal weapon bays of stealth fighters or triple the magazine depth on the external weapon stations of nonstealth aircraft, says Mark Noyes, vice president of business development and strategy for Raytheon Missile Systems. The Peregrine missile is being pitched to U.S. Air Force officials confirmed the ongoing development of the Lockheed Martin AIM-260, which is intended to replace the AIM-120 with a longer-range missile of the same length. 16 at the Air Force Association's annual National Convention in Washington comes just three months after U.S. The unveiling of a Peregrine mockup on Sept. Raytheon has unveiled an internally funded program to develop a new air-to-air missile called Peregrine that combines the reach of the medium-range AIM-120 and the maneuverability of the short-range AIM-9X, but in a smaller form factor to increase the magazine depth of tactical aircraft. scrapped plans for a sequel, opting instead to use Man of Steel (2013) as the official start of the DC Extended Universe, two years after Green Lantern 's release. However, due to the film's critical and commercial failure, Warner Bros. It was also originally intended to start a film franchise based on DC characters. The film was one of the biggest box-office bombs in history, grossing $220 million against a production budget of $200 million. Pictures to negative reviews, with criticism aimed at its script, tone, visual effects, and unfaithfulness to the source material. Green Lantern was released in the United States on Jby Warner Bros. The film was converted to 3D during its post-production stage. Most of the live-action actors were cast between July 2009 and February 2010, and filming took place from March to August 2010 in Louisiana. Martin Campbell was brought on board in February 2009 after Berlanti was forced to vacate the director's position. The film first entered development in 1997 progress remained stalled until Berlanti was hired to write and direct in October 2007. The film tells the story of Hal Jordan, a test pilot who is selected to become the first human member of an intergalactic police force called the Green Lantern Corps he is given a ring that grants him superpowers, and must confront Parallax, a being who threatens to upset the balance of power in the universe, while a new threat rises back on Earth. This was the first DC film since Catwoman (2004) not to be involved with Legendary Pictures. The film stars Ryan Reynolds, Blake Lively, Peter Sarsgaard, Mark Strong, Angela Bassett, and Tim Robbins, with Martin Campbell directing a script by Greg Berlanti and comic book writers Michael Green and Marc Guggenheim, which was subsequently rewritten by Michael Goldenberg. Green Lantern is a 2011 American superhero film based on the DC Comics character of the same name. In addition, the WD Sync alternative – MiniTool ShadowMaker enables you to save the backup images to different destinations including Administrator, Libraries, Computer, Network and Shared folders.Īs an alternative to the Western Digital Sync software, MiniTool ShadowMaker also enables you to sync files or folders to keep your data safe because it is also a piece of file sync software. It is able to help you to back up the disk, partition, files, folders and the operating system. MiniTool ShadowMaker is a piece of professional Windows backup software. Read More WD Sync Alternative Software for Windows – MiniTool ShadowMaker Induction on WD Sync Alternative Software for Windows Thus, MiniTool ShadowMaker is strongly recommended. To sync files and folders, you can take advantage of a piece of professional file sync software. Thus, is there any alternative to the WD Sync software to sync your files? The answer is positive. It only works when you have the My Cloud Device or you have the M圜loud account. Moreover, the supported device is also limited. For example, it doesn’t support you to sync files to another hard drive. However, to sync files to the My Cloud Device, the WD Sync software is a little complicated. When you have finished all steps, you have successfully synchronized the files and folders to the My Cloud Device to keep your data safe. Click Next to continue.Ĥ. At last, click the Finish button to complete the file synchronization process. Check the folder you want to sync or uncheck the folder and files you don’t want to sync. After you have selected the My Cloud Device, you are required to choose the files and folders to sync. Step 3: Start to sync files to My Cloud Deviceġ. You can choose one My Cloud Device to continue. Then you can find that all My Cloud Devices associated with the account are listed here. Note: If the WD Sync software doesn’t find the My Cloud Device, you can click Sign in to enter the M圜 account. However, do you know how to use the WD Sync utility? Or when the WD sync fails to work, how can you keep data safe? In the following content, this post will show you the solutions. So if you are a user of Western Digital hard drive and want to sync files to the My Cloud Device, you can download the WD Sync and start to sync files so as to keep your data safe. The WD Sync for Windows can support the Windows 10/8.1/8/7. But it doesn’t support you to sync files to a hard drive. This WD Sync software can help you to sync your files and folder to the My Cloud Device. WD Sync is a utility of Western Digital that allows you to sync files to the My Cloud Device on your network. WD Sync VS MiniTool ShadowMaker VS Sync Center.WD Sync Alternative for Windows – Sync Center. WD Sync Alternative Software for Windows – MiniTool ShadowMaker.And this post also introduces WD Sync alternatives to help you to sync files to another hard drive. The WD Sync software allows you to sync files to the My Cloud Device. In order to keep data safe, users may choose to sync files to another location. Double click inside the Streets of Rogue folder and run the exe application.zip file and click on “Extract to Streets.of.” (To do this you must have 7-Zip, which you can get here). Once Streets of Rogue is done downloading, right click the.Now let the download begin and wait for it to finish. Wait 5 seconds and click on the blue ‘download now’ button. Click the Download button below and you should be redirected to UploadHaven.How to Download & Install Streets of Rogue Lead a gang, free slaves, drink beer, gib ghosts, become a vampire, shrink people and stomp on them.4-Player online and local cooperative modes lets you brutalize goons AND loneliness!.Stupidly huge variety of items! Shrink rays, hypnotizing devices, boomboxes, bear traps, food processors.Play as over 20 (and growing!) wildly different types of characters! Bartender, scientist, hacker, gorilla - hey, your job is probably in there too!.Super-advanced artificial intelligence that won’t put up with your crap! Outsmart these virtual humans and feel superior to your computer!.Random world generation and TOTALLY EXTREME gameplay variety means you can play for 600 hours and not get bored! Seriously though, go outside!!!.Play the game YOUR way! Don’t want to kill anybody? That’s cool! Want to hack computers? Got ya covered!.In order to progress, the player will need to accomplish specific mission goals in any way they see fit through use of their special character traits, items, and the environment. Rather than taking place in a dungeon, the game is set in a functioning, procedurally generated city, where complex AI informs denizens from all walks of life, who are just trying to get by in their daily activities. The game takes inspiration from fast-paced top-down rogue-lites like Binding of Isaac and Nuclear Throne, and adds free-form, experimentation-driven, emergent gameplay elements of RPGs like Deus Ex. Streets of Rogue is a rogue-lite about player choice, freedom, and anarchic fun. When searching through hundreds of products sometimes that one sound your looking for remains consistently allusive hidden in a jumble of poorly labelled folders and hard to access back ups.īelow we will outline three ways each of us here at 8Dio use to load our vast catalogue of products. With a growing catalogue of instruments and an almost unlimited amount of possibilities loading your libraries into Kontakt can either become a chore, or a pleasure. The modulation wheel usually sends MIDI CC #1 data, volume and expression pedals CC #7 and #11, respectively.How To Load Libraries Into Kontakt - "8Dio How To Series" Showcases how to load libraries into Native Instruments Kontakt. MIDI CC Number (only visible if source is MIDI CC): The modulation will acquire its values from incoming MIDI controller data with the number specified here. Once you’re finished with your adjustments down there, the identical button on the panel will bring you back to where you came from. Quick-Jump button (only visible on internal source assignments, like LFOs): Clicking on this button will immediately scroll down to the respective source’s control panel at the bottom of the Rack. Modulation Source: If the entry belongs to an internal source assignment, this value can’t be modified, but external source assignments will offer a drop-down menu here that allows you to switch to a different source. Others include sources that don’t fit into one of the other categories, such as step sequencers or envelope followers. In addition to the traditional set of waveforms found on synthesizers - namely Sine, Triangle, Rectangle, Sawtooth, and Random - Kontakt also provides a complex LFO, which generates a mixture of these waveforms.Įxternal Sources provide access to control signals that are generated outside of Kontakt’s modulation source modules, such as incoming MIDI data, or constant and random values. LFOs (Low Frequency Oscillators) are sources that generate a periodic waveform within a frequency range of 0.01 Hz up to about 210 Hz. Envelopes generally react to MIDI note messages. Of course, the example can be just as easily replicated in Kontakt: the Source Module will become your tone generator, its Tune parameter your pitch knob, an LFO your source of a low-frequency control signal, and an entry in the Modulation Router the wire that connects both generators.Įnvelopes are finely adjustable curves of varying shapes, which have a beginning and an end these are usually being used for creating parameter changes, often non-repetitive, that can’t be easily obtained from a traditional periodic waveform, such as a filter that opens and then gradually closes again after a key has been pressed. This is a very simple example of modulation: you’re using a generated control signal (which can be periodic, but doesn’t have to) to change some parameter over time. Now, the tone generator’s pitch will begin to periodically sweep up and down “around” the pitch you’ve adjusted with the knob, in other words: vibrato. Instead, you can use another generator that outputs a periodic waveform as well - though at a much lower frequency than your tone generator, let’s say 5 Hz - and connect it to the pitch control of your tone generator. Of course, rapidly moving the pitch knob left and right is an option, but this is awkward and inconvenient. As players of acoustic instruments often use vibrato - a subtle “trembling” of the pitch - as a means to make their sound more expressive and dynamic, you’d like to simulate this effect with your generator. Suppose you have a very simple tone generator with only one control, which changes the pitch of the generated tone. If you already have worked with modulation, just skip the next paragraph. If you’re new to synthesizers and samplers, you might be unfamiliar with the concept of modulation, so we’ll explain it briefly. For this purpose, most of Kontakt’s modules provide a table, called the Modulation Router, which allows you to assign various sources of modulation signals to that respective module’s parameters. Kontakt’s internal modulation system offers a powerful way to “animate” parameters, making them change over time in a variety of different and finely adjustable ways. Signal Processors in the Outputs Sectionįrom a basic explanation of modulation to using Kontakt's Modulation Router to connect sources with parameters, learn how to make your sound more dynamic with modulation.Assigning MIDI Controllers in the Side Pane.Loading and Saving Instruments and Multis.Loading a Snapshot from the File System. |
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